Cagrilintide

Cagrilintide is a long-acting synthetic analog of amylin, a peptide hormone co-secreted with insulin by the pancreatic beta cells. Research has looked at its interactions with the amylin and calcitonin receptor family and its role in appetite and satiety signaling.

Overview

Cagrilintide is a synthetic long-acting amylin analogue that has been widely studied in laboratory settings for its interaction with amylin receptors and biological pathways involved in appetite regulation, energy balance, and metabolic signalling. It is supplied exclusively for controlled laboratory and research use and is intended only for qualified scientific investigation.

As part of Retro Wellness’ research compound range, Cagrilintide is presented with a focus on consistency, quality, and responsible sourcing. Each product is intended strictly for qualified research settings and should only be handled by individuals or organisations with the appropriate facilities, knowledge, and procedures.

Research involving Cagrilintide has explored its interaction with biological pathways associated with amylin receptor activation, gastric emptying, satiety signalling, glucose regulation, and central nervous system pathways involved in energy homeostasis. It has also been investigated in broader studies examining metabolic function, endocrine communication, and combination research alongside GLP-1 receptor agonists across a range of experimental models. Ongoing research continues to expand understanding of its biological activity and potential relevance within metabolic, endocrine, and molecular research.

This product is not a medicine, supplement, cosmetic, or food product. It is not intended for human or veterinary use, diagnosis, treatment, prevention, or consumption.

What Research Has Explored

  • Long-acting synthetic analog of the pancreatic hormone amylin
  • Research has looked at its binding to amylin and calcitonin receptors
  • Studied in the context of appetite and satiety signaling pathways
  • Investigated both on its own and alongside semaglutide in research settings

How It Works

Cagrilintide is a structurally modified, long-acting analog of human amylin (also called islet amyloid polypeptide, or IAPP), a 37-amino acid hormone released alongside insulin from the pancreatic beta cells. Changes to the native sequence and the addition of a fatty acid chain were designed to improve solubility and extend its half-life, which has allowed once-weekly dosing in research settings. Amylin signals through a family of receptors formed when the calcitonin receptor pairs with receptor activity-modifying proteins (RAMPs). Research has looked at how cagrilintide binds across both the calcitonin receptor and these amylin receptor subtypes, and structural studies have characterized the details of that binding. Studies have also examined cagrilintide’s activity at amylin receptors in the brain — particularly in regions involved in appetite and satiety signaling — and have investigated it both as a single agent and in combination with the GLP-1 receptor agonist semaglutide in research models.

Research Sources

Frequently Asked Questions

A long-acting synthetic analog of the pancreatic hormone amylin.
Amylin and calcitonin receptor binding, appetite and satiety signaling, and studies alongside semaglutide.
Receptor complexes formed when the calcitonin receptor pairs with receptor activity-modifying proteins.
No. This information is provided only for educational and research reference.
Product Name
Cagrilintide
Formulation
Lyophilized Powder
Strength
5 mg, 10 mg
Purity
>99% (HPLC)
Molecular Formula
n/a
Sequence
n/a
Cas Number
n/a

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For Qualified Laboratory Research Use Only

All products available on this site are supplied strictly for laboratory research use only. They are not intended for human or veterinary use, consumption, treatment, diagnosis or therapeutic application. Customers are responsible for ensuring products are handled, stored and used appropriately within a suitable research setting.