CJC-1295 (No DAC)

CJC-1295 (No DAC) is a synthetic 29-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH). It features four amino acid substitutions that confer resistance to enzymatic degradation, extending its biological activity compared to native GHRH.

Overview

CJC-1295 (No DAC), also known as Modified GRF 1-29, is a synthetic peptide that has been widely studied in laboratory settings for its interaction with growth hormone-releasing hormone (GHRH) receptors and associated endocrine signalling pathways. It is supplied exclusively for controlled laboratory and research use and is intended only for qualified scientific investigation.

As part of Retro Wellness’ research compound range, CJC-1295 (No DAC) is presented with a focus on consistency, quality, and responsible sourcing. Each product is intended strictly for qualified research settings and should only be handled by individuals or organisations with the appropriate facilities, knowledge, and procedures.

Research involving CJC-1295 (No DAC) has explored its interaction with biological pathways associated with pulsatile growth hormone secretion, pituitary receptor activation, insulin-like growth factor-1 (IGF-1) regulation, endocrine communication, and neuroendocrine signalling. It has also been investigated in broader studies examining hormonal regulation, metabolic signalling, and cellular communication across a range of experimental models. Ongoing research continues to expand understanding of its biological activity and potential relevance within endocrine, metabolic, and molecular research.

This product is not a medicine, supplement, cosmetic, or food product. It is not intended for human or veterinary use, diagnosis, treatment, prevention, or consumption.

What Research Has Explored

  • Potential to increase natural growth hormone release
  • May elevate IGF-1 levels for extended periods
  • Mimics natural pulsatile hormone release patterns
  • Often studied alongside Ipamorelin for enhanced effects

How It Works

CJC-1295 without DAC (Modified GRF 1-29) mimics endogenous GHRH but with enhanced stability. The “No DAC” form has a shorter half-life (~30 minutes) compared to the DAC version (6-8 days), resulting in pulsatile rather than sustained GH elevation. CJC-1295 binds to GHRH receptors on somatotroph cells in the anterior pituitary gland, initiating intracellular signaling. Receptor activation stimulates adenylyl cyclase, increasing cyclic AMP production and triggering protein kinase A phosphorylation cascades. PKA activation enhances growth hormone gene transcription and protein synthesis within pituitary somatotrophs. The short half-life of the No DAC form produces GH release in pulses, potentially avoiding receptor desensitization associated with continuous stimulation. Released GH stimulates hepatic production of IGF-1, a key mediator of GH’s anabolic effects.

Research Sources

Frequently Asked Questions

A synthetic 29-amino acid analog of growth hormone-releasing hormone, also called Modified GRF 1-29.
GHRH receptor signaling, growth hormone release, IGF-1 physiology, and pulsatile hormone patterns.
It is described as shorter acting than the DAC-conjugated form.
No. This information is provided only for educational and research reference.
Product Name
CJC-1295 (No DAC)
Formulation
Lyophilized Powder
Strength
10 mg
Purity
>99% (HPLC)
Molecular Formula
n/a
Sequence
n/a
Cas Number
n/a

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For Qualified Laboratory Research Use Only

All products available on this site are supplied strictly for laboratory research use only. They are not intended for human or veterinary use, consumption, treatment, diagnosis or therapeutic application. Customers are responsible for ensuring products are handled, stored and used appropriately within a suitable research setting.